The 'Doktor, Turn Off My Pain Inhibitors' meme stems from a pivotal moment in the 2013 action game Metal Gear Rising: Revengeance. During a confrontation with the boss Monsoon, the protagonist Raiden commands his technical advisor, Doktor, to disable the cybernetic systems that prevent him from feeling physical pain, allowing him to tap into his bloodthirsty 'Jack the Ripper' persona. The scene became an internet sensation due to its over-the-top voice acting and dramatic stakes. In meme culture, it is typically used as a reaction to something emotionally or mentally agonizing, signaling that the user is about to subject themselves to something painful—such as reading toxic social media threads or revisiting embarrassing memories—with a sense of grim, hyperbolic determination.