The 'Nanomachines, Son' meme originates from the 2013 action game Metal Gear Rising: Revengeance, specifically during the climactic final boss battle between Raiden and Senator Steven Armstrong. When Raiden asks how Armstrong is able to withstand his superhuman attacks, the Senator triumphantly reveals his body is hardened by 'nanomachines' that respond to physical trauma. This line, delivered with over-the-top bravado, became an instant internet classic used to mock plot armor, explain away impossible feats, or justify absurdly durable objects and characters. Its popularity surged years after the game's release through high-quality 3D animations and status-style videos, cementing Armstrong as one of gaming's most meme-able antagonists.