The 'Most Ambitious Crossover Event in History' meme stems from a promotional tweet by Marvel Studios in 2018 regarding the release of Avengers: Infinity War. Internet users quickly began parodying the claim by pairing the caption with screenshots of unexpected or humorous character meetings from television, video games, or real life that predated the film. The meme highlights the absurdity of marketing hyperbole by showcasing bizarre pop-culture intersections, such as The Jetsons meeting The Flintstones or niche commercial cameos. It remains a staple for celebrating or mocking the chaotic energy of different intellectual properties colliding in one frame.