The 'Cheers, I'll drink to that, bro' meme originates from a surreal segment on Adult Swim’s 'The Eric Andre Show,' specifically featuring Andre’s hyper-active 'Ranch It Up' persona. Dressed in neon gear and embodying the ultimate 'bro' stereotype, Andre delivers the line with chaotic energy while holding a drink. The clip gained massive traction on Vine and YouTube before evolving into a versatile reaction image used to express enthusiastic agreement. It is most commonly applied to relatable daily struggles, unpopular opinions that people secretly agree with, or simply to toast to a job well done in the most absurd way possible.