The Blank Comic Panel 2x2, also known as the 4-panel grid, is the foundational building block of internet comic culture. While it doesn't have a single origin point like viral videos, its popularity surged through webcomic platforms and early internet forums where users needed a simple structure for 'setup-setup-twist-reaction' storytelling. This specific 2x2 layout is the gold standard for visual jokes, allowing creators to establish a scenario, build tension, and deliver a punchline within a compact, easily shareable format. It remains the most versatile template for everything from political satire to wholesome character interactions.