The 'Blackjack and Hookers' meme originated from the animated series Futurama, specifically the episode 'The Series Has Landed' which aired in 1999. In the scene, Bender is kicked out of the Lunar Park and spitefully declares he will build his own theme park, famously adding, 'With blackjack and hookers!' This catchphrase evolved into a popular internet meme used to express defiance or the intent to create a superior alternative after being rejected. It is typically accompanied by an image of Bender looking confident or annoyed, symbolizing a humorous take on starting over with self-indulgent additions.