The Futurama meme collection, led by the legendary 'Not Sure If' Fry template, features the protagonist Philip J. Fry squinting his eyes in suspicion. This iconic image originated from the Season 2 episode 'The Lesser of Two Evils' and transitioned into an internet sensation around 2010. It is primarily used as an internal monologue to express skepticism or the difficulty of distinguishing between two similar scenarios, typically following the 'Not sure if X or Y' format. The show's sharp writing and expressive characters have birthed numerous other massive templates like 'Shut Up and Take My Money' and 'I Don't Want to Live on This Planet Anymore,' making Futurama a cornerstone of modern meme culture.