The 'Assburger' meme primarily stems from a 2011 episode of the animated series South Park titled 'Ass Burgers.' In the episode, Eric Cartman mishears the medical diagnosis of Asperger's Syndrome as 'Ass Burgers' and proceeds to literally shove hamburgers down his pants to sell them, claiming they have a unique flavor. The meme has since evolved into a general play on words, often used to mock misunderstandings of medical terms or as a crude pun. It captures the essence of shock humor and juvenile wordplay that the show is famous for, and it remains a staple in communities that enjoy satirical or irreverent internet culture.