The 50 Cent driving meme originates from a cameo appearance by the rapper in the HBO series 'Entourage.' In the scene, 50 Cent pulls up in a convertible next to his real-life rival Ja Rule, laughs mockingly at him, and then speeds away. This moment became internet gold as a reaction image or GIF to represent petty behavior, avoiding responsibilities, or simply laughing at someone else's misfortune. It is widely used to illustrate situations where someone observes a mess or an awkward encounter and chooses to drive right past it with a satisfied smile.