The Yuko with Gun meme features Yuko Aioi, the energetic protagonist from the surreal comedy anime 'Nichijou.' While the series is known for its over-the-top reactions, the image of Yuko wielding a firearm is typically an edit or a capture of her most frantic, desperate moments. It gained massive popularity in the late 2010s across Twitter and Discord as a 'Delete This' reaction image. The meme perfectly captures the chaotic energy of the show, used by fans to signal extreme frustration or to jokingly threaten someone over a bad take online.