The 'Your Boos Mean Nothing' meme originates from the Season 4 episode of Rick and Morty titled 'One Crew over the Crewcoo's Morty.' In the scene, Rick Sanchez silences a heckling crowd with the biting retort: 'Your boos mean nothing to me, I've seen what makes you cheer.' This quote instantly resonated with internet users as the ultimate defense against collective criticism. It is used to highlight the hypocrisy or poor taste of one's detractors, suggesting that their disapproval is actually a validation of one's own superior choices. The meme is a favorite for those defending unpopular opinions, niche hobbies, or controversial creative decisions.