The 'Won't You Shake A Poor Sinner's Hand' meme originates from a viral TikTok trend featuring Dr. Facilier’s song 'Friends on the Other Side' from Disney's The Princess and the Frog. The trend typically involves creators lip-syncing to the villainous invitation, often paired with dramatic lighting or quick cuts to represent a 'deal with the devil' or a sudden transformation. It became a staple for videos showcasing glow-ups, questionable life choices, or intense transitions. The 'Are You Ready?' buildup followed by the offer of a handshake serves as the perfect template for any scenario where someone is about to dive into a risky but tempting situation.