Willem Dafoe has become a staple of internet culture thanks to his incredibly expressive face and legendary film roles. The most prominent templates include the 'Looking Up' shot from the 2018 film 'At Eternity's Gate,' where Dafoe depicts Vincent van Gogh in a moment of overwhelmed despair, and the iconic 'I'm something of a scientist myself' line from 2002's Spider-Man. These memes are widely used to represent feelings of impending doom, intense realization, or sarcastic displays of expertise. Dafoe's ability to oscillate between manic energy and profound sorrow makes his image the perfect canvas for reacting to everything from minor inconveniences to existential crises.