The 'Who Can It Be Now?' Osaka meme features Ayumu 'Osaka' Kasuga from the classic slice-of-life anime Azumanga Daioh, often paired with the rhythmic saxophone intro of the 1981 hit by Men at Work. Osaka is celebrated in the meme community for her legendary 'brain-empty' expressions and frequent zoning out, making her the ultimate mascot for absurdist and surreal humor. The trend typically involves Osaka staring blankly into the camera or appearing in unexpected places, perfectly synced to the song's paranoid lyrics. It gained massive popularity on platforms like TikTok and YouTube, evolving into a staple of anime 'brain rot' culture where her vacant gaze represents everything from social anxiety to pure, unadulterated thoughtlessness.