The 'What's Wrong Big Boy?' meme originates from a webcomic panel created by artist @Gatobob, originally featuring a tall, intimidating character leaning over a smaller, intimidated one. While the original dialogue was more suggestive, the internet quickly adapted the template to depict various scenarios involving power imbalances, social anxiety, or awkward confrontations. It gained significant traction on platforms like Twitter and Tumblr, where users swap out the characters to represent different fandoms or relatable life experiences. Today, it serves as the ultimate visual shorthand for being overwhelmed by something—or someone—much larger than yourself.