The 'What's in Your Brain?' meme typically utilizes a cross-section diagram of a human brain or a character's head to humorously depict their internal priorities. By partitioning the brain into different sections and labeling them with obsessions, anxieties, or trivial facts, users create a relatable map of the human psyche. It gained massive traction on platforms like Reddit and Twitter as a way to express self-deprecating humor about overthinking or having a brain 'full' of useless information while forgetting important tasks. The template remains a popular choice for showcasing niche interests and the chaotic nature of modern thought processes.