The 'What Has Science Done?' meme is a classic internet reaction used to highlight bizarre, unsettling, or absurd creations that seem to defy common sense. Originating in the mid-2000s on forums like 4chan and Something Awful, the phrase was often paired with images of strange Photoshop hybrids, such as the infamous 'human-dog' or weird taxidermy. It perfectly captures a sense of mock disbelief at human ingenuity gone 'too far.' Today, the meme continues to thrive as a reaction to cursed images, questionable AI-generated content, and questionable culinary experiments, serving as the ultimate response to anything that looks like a mad scientist's mistake.