The Vatican Snake Room meme centers on the Paul VI Audience Hall in Vatican City, a structure completed in 1971 by architect Pier Luigi Nervi. The meme gained traction online when viewers noted that the building's interior, specifically when viewed from the back of the hall, bears a striking and uncanny resemblance to the head of a giant serpent—with stained glass windows acting as eyes and the stage appearing as the fangs and mouth. Conspiracy theorists often use this imagery to suggest reptilian or illuminati influence within the Catholic Church, while internet users more broadly use it to meme villainous or eerie architectural designs. It has become a staple in paranormal and conspiracy-themed communities to spark debate or simply highlight strange visual coincidences.