The scene from 'Three Amigos' features a humorous interaction between the characters, wherein one asks the meaning of the word 'plethora.' This moment has become iconic and is often referenced in various meme formats due to its comedic timing and absurdity. Memes created from this scene highlight misunderstandings or over-exaggerated reactions, playing off the characters' naivety and the bewildering nature of the question. It showcases how simple dialogue can transcend its original context and pop into popular culture.