The Opie & Anthony Show, a cornerstone of shock radio, has fostered a massive online subculture known for its dark humor and relentless 'pest' community. Memes surrounding the show often target the hosts' eccentricities, legendary guests like Patrice O'Neal, and the chaotic studio environment that defined satellite radio in the 2000s. While the show went off the air years ago, its legacy lives on through viral clips and image macros that capture the essence of 'the virus.' These memes are frequently used within comedy circles to mock awkward social interactions or to pay homage to the unapologetic, filter-free era of talk radio.