The Binding of Isaac memes stem from the dark, rogue-like indie game created by Edmund McMillen, known for its grotesque imagery and intense difficulty. The most popular templates usually feature Isaac, the protagonist, in states of extreme distress, crying, or occasionally celebrating a rare 'Quality 4' item. These memes perfectly capture the 'skill issue' culture and the love-hate relationship players have with the game's unpredictable RNG. From the distraught Isaac face to the 'Specialist Dance' mod, these images are used throughout the gaming community to describe moments of profound bad luck or unexpected triumph in both the game and real-life scenarios.