Based on the hit light novel and anime series TenSura, 'That Time I Got Reincarnated as a Slime' memes capitalize on the show's unique premise and the protagonist Rimuru's dual nature as a cute blob and an omnipotent demon lord. The meme format often parodies the trend of excessively long isekai titles or uses Rimuru’s expressive reactions to contrast simple situations with overwhelming power. Since the anime's debut in 2018, fans have used these templates to celebrate the 'OP Protagonist' trope, frequently placing Rimuru in crossover scenarios or using his 'smug' and 'shocked' faces to represent relatable everyday struggles.