The 'Ted Cruz Zodiac Killer' meme is a satirical conspiracy theory that gained massive traction during the 2016 US Presidential campaign. It began as a joke on Twitter in 2013, suggesting that the Senator was responsible for the unsolved crimes of the 1960s, despite Cruz being born after the murders began. The meme's absurdity led to it becoming a viral sensation, eventually being acknowledged by Cruz himself and referenced in mainstream political discourse. It is typically used to mock the Senator or as a surreal piece of internet lore, representing the chaotic and humor-driven nature of modern political commentary.