The 'What’s Up Brother?' meme features the energetic Twitch streamer Sketch, whose real name is Kylie Cox, known for his Madden gameplay and quirky persona. The meme took off in 2024 when a clip of Sketch greeting his chat with his index finger raised became an overnight sensation on TikTok and Twitter. Its popularity peaked when professional sports teams and athletes began recreating his signature 'Tuesday Tuesday' catchphrase and awkward-yet-confident posture. The meme is used to convey a wholesome but chaotic energy, often appearing in videos where people surprise their friends or partners by mimicking Sketch's distinct voice and mannerisms.