The 'Shut Up Grandma, Drink Your Prune Juice!' meme originates from the 2005 comedy film 'Wedding Crashers,' featuring Vince Vaughn’s character, Jeremy Grey. During a chaotic family dinner scene, Jeremy snaps at the elderly grandmother to silence her eccentric outbursts. The phrase quickly became a cultural touchstone for shutting down unwanted or annoying comments, especially from older individuals or those being overly dramatic. In internet culture, the meme is used to dismiss unsolicited advice or to humorously tell someone to stay in their lane. Its longevity is fueled by its relatable frustration and the absurdity of using prune juice as a peace-making tool.