The 'Sheeeeee-it' meme originates from the HBO crime drama series The Wire, specifically associated with the corrupt yet charismatic Senator Clay Davis, played by Isiah Whitlock Jr. The character became famous for his signature, drawn-out pronunciation of the word 'shit' whenever he was confronted with bad news, surprising revelations, or complex political maneuvers. Over time, the phrase transcended the show to become a staple of internet reaction culture, used to express incredulity, mock surprise, or exasperation. Its popularity is bolstered by Isiah Whitlock Jr. himself, who has embraced the catchphrase, ensuring its place as a legendary piece of television and meme history.