The River City Girls meme stems from the 2019 revival of the classic Kunio-kun franchise, featuring high schoolers Misako and Kyoko as they fight their way across town to rescue their boyfriends. Known for its vibrant pixel art and high-energy personalities, the game quickly became a favorite for meme creators who use the girls' expressive animations to depict fierce loyalty, chaotic energy, or sudden outbursts of violence. Most memes utilize official promotional art or in-game cutscenes to highlight the contrast between their cute aesthetic and their 'punch first, ask questions later' attitude. It is frequently used in gaming communities to represent aggressive enthusiasm or the feeling of teaming up with a best friend to take on any challenge.