The 'Regular Dudes Super Mario Loss' meme originates from a popular sketch by the digital comedy group 'Regular Dudes' (primarily featuring Zack and Chris) released around 2022. In this specific 22-second clip, the characters are shown in a state of high-intensity focus while playing a Super Mario title, only for the session to end in a devastating and sudden loss. The scene captures the raw, silent tension that occurs between friends when a high-stakes gaming moment goes wrong, characterized by the stunned silence and blank stares of the actors. This clip is widely used to illustrate scenarios involving extreme disappointment, the 'silent rage' of losing progress, or the awkward atmosphere following a major mistake in a group setting. It perfectly represents the relatable feeling of being completely 'done' with a situation. Example captions include: 'When you spend 3 hours on a boss and die to a glitch,' or 'Me and the boys after the 1:00 AM motivation suddenly leaves our bodies.'