The 'Professor X Has ONE Weakness' meme playfully mocks the juxtaposition between Charles Xavier’s god-like telepathic abilities and his physical limitation as a wheelchair user. Usually featuring a dramatic comic book panel or a still from the X-Men films, the punchline reveals a mundane physical obstacle—most famously, a flight of stairs or a lack of ramps. It evolved from early internet 'anti-humor' and Marvel fan circles, highlighting the irony that the world's most powerful mind can be defeated by basic structural barriers. Today, it is widely used to represent any situation where a high-powered individual is thwarted by a trivial, everyday problem.