This meme template is based on the opening sequence of the 1998 animated series The Powerpuff Girls. It depicts Professor Utonium attempting to create the perfect little girls by combining sugar, spice, and everything nice, only to accidentally add the mysterious Chemical X. In the meme world, this multi-panel format is used to illustrate the chaotic or unexpected ingredients that make up a specific personality, event, or product. The humor typically stems from the final panel where the addition of Chemical X, representing a specific flaw or a dominant trait, completely alters the final result.