The 'Powder That Makes You Say Yes' meme is based on a webcomic from the 'Bluechair' series by artist Shenanigansen (Shen Comix). In the original four-panel comic, a character finds a container labeled 'Powder that makes you say yes,' consumes it, and predictably responds with 'Yes' when asked a follow-up question. The meme gained massive popularity as an 'anti-joke' or 'Bone Hurting Juice' style edit, where users replace the label on the jar and the final response to create literal or absurdly logical scenarios. It remains a staple of internet culture due to its clean layout and the expressive, relatable character design typical of Shen's work.