Pain Peko is a popular reaction image and catchphrase featuring the Hololive VTuber Usada Pekora looking visibly depressed or defeated. The phrase is a portmanteau of the word 'pain' and Pekora's signature verbal tic, 'peko,' which she famously adds to the end of her sentences. The meme typically uses a desaturated fan art image of the rabbit-eared idol, capturing a mood of profound, yet often ironic, sadness. Originating within the VTuber fandom on platforms like Twitter and Reddit, it quickly transcended its niche to become a universal internet shorthand for expressing disappointment, bad luck, or existential dread in a cute yet tragic way.