The Oxford Comma meme centers on the 'serial comma' used before the final conjunction in a list. The meme gained internet fame through viral illustrations showing how omitting the comma can lead to absurd misinterpretations, such as implying that two distinct items in a list are actually descriptions of the first person mentioned. Common examples include the infamous 'strippers, JFK, and Stalin' versus 'the strippers, JFK and Stalin,' which humorously suggests the world leaders are the performers. It is a staple in academic, literary, and design circles, used to mock the ambiguity of English grammar and to settle the eternal debate between AP Style and Chicago Style enthusiasts.