The 'Oprah's Shocked Reaction' meme stems from the high-profile CBS interview with Prince Harry and Meghan Markle aired in March 2021. The specific image captures Oprah Winfrey's genuine expression of astonishment, characterized by her raised hands and wide-open mouth, following a particularly bombshell revelation about the British Royal Family. Almost immediately after the broadcast, the clip went viral on social media platforms like Twitter and TikTok, becoming a universal shorthand for hearing shocking gossip or experiencing utter disbelief. It is widely used to react to 'tea' being spilled, unexpected plot twists, or moments where words simply aren't enough to convey how stunned one truly is.