The 'One Piece' memes, most notably the 'The One Piece is Real' variant, stem from the iconic scene in the anime/manga where Edward 'Whitebeard' Newgate declares the treasure's existence before his death at Marineford. This specific moment saw a massive resurgence in 2022 across TikTok and Twitter, often paired with the song 'Dark Fantasy' by Kanye West. The meme typically features distorted images of the characters and is used to express grand revelations, irony, or surreal humor. It has since expanded to include various character reactions, making it a staple of anime internet culture.