The Once Upon a Time in Hollywood poster parody stems from the marketing release of Quentin Tarantino’s 2019 film. Fans quickly noticed the distinct, retro aesthetic featuring stars Leonardo DiCaprio, Brad Pitt, and Margot Robbie, which invited endless creative edits. The meme involves replacing these actors with unlikely duos from other movies, video games, or real-life viral moments, often changing the title to 'Once Upon a Time in...' followed by a specific location or subculture. It serves as a versatile way to celebrate or mock iconic partnerships, utilizing the film's nostalgic vibe to add a sense of cinematic importance to mundane or chaotic situations.