The 'Not Scientifically Possible' meme originates from the 2019 Netflix film Invader Zim: Enter the Florpus. In the scene, Professor Membrane, a brilliant but stubborn scientist, intensely shouts the phrase while rejecting a claim that challenges his scientific worldview. The clip gained immediate viral traction on platforms like YouTube and Twitter due to the character's exaggerated voice acting and dramatic animation. It is commonly used as a reaction image or video to mock absurd logic, highlight impossible situations, or aggressively dismiss someone's statement, no matter how trivial the subject might be.