The Nice Guy Loki meme evolved from the character's complex journey in the Marvel Cinematic Universe, particularly following his transition from a primary antagonist to a fan-favorite anti-hero. The meme typically uses images of Tom Hiddleston looking surprisingly earnest or charmingly polite, juxtaposing his 'God of Mischief' title with 'Nice Guy' behavior. It often pokes fun at the character's attempt at redemption or is used ironically to describe someone being suspiciously helpful. It became a staple in Marvel fandom circles for highlighting Loki’s more human and relatable moments.