The 'Never Go Against the Family' meme originates from the 1972 cinematic masterpiece, The Godfather. The line is famously delivered by Michael Corleone to his brother Fredo after Fredo sided with Moe Greene, serving as a chilling reminder that loyalty to the Corleone family is absolute. In internet culture, the template is used both seriously and satirically to highlight unwavering allegiance. It often features Don Vito Corleone or Michael Corleone and is frequently applied to niche hobbies, sports teams, or corporate brands where 'the family' represents a dedicated community that one must never betray.