The Naruto Handshake meme is a creative anime-themed reimagining of the legendary 'Epic Handshake' from the 1987 film Predator. Typically featuring Naruto Uzumaki and Sasuke Uchiha—or sometimes Hashirama Senju and Madara Uchiha—it represents a powerful, often unlikely, agreement between two forces. While the original anime scenes symbolize the resolution of long-standing rivalries and the 'Cycle of Hatred,' the meme is used humorously online to show two different groups or people finding common ground over a shared, often niche, interest or opinion.