The 'Nani Sore' meme originates from the 2013 Studio Trigger anime series Kill la Kill, specifically spoken by the character Nonon Jakuzure. Translated from Japanese as 'What is that?' or 'What are you talking about?', the phrase became a viral catchphrase due to Nonon's distinct, high-pitched, and condescending delivery. Fans quickly adopted the scene as a reaction image to express disbelief, confusion, or sass when confronted with something nonsensical. It remains a staple in the anime community, often paired with absurd situations or illogical internet arguments where a simple, sassy question is the only appropriate response.