The 'Mukuro Ikusaba, the 16th Student' meme originates from the Danganronpa: Trigger Happy Havoc visual novel and anime series. It refers to a specific, repetitive piece of dialogue used to warn the player about a hidden participant in the killing game. The phrase—'Mukuro Ikusaba, the sixteenth student, lying hidden somewhere within this school... the one they call the Ultimate Despair. Watch out for her'—became a community staple due to its over-the-top delivery and frequent repetition across various media formats. Fans often use it as a bait-and-switch copypasta, injecting the ominous warning into completely unrelated discussions to surprise fellow players or poke fun at the series' dramatic foreshadowing.