The 'Most People Rejected His Message' meme is derived from a 1964 religious tract titled 'This Was Your Life!' created by Jack Chick. The specific panel shows a figure delivering a message to an angry crowd, accompanied by the narration 'They hated him because he told them the truth.' It became a viral sensation in the mid-2010s as a way to frame controversial opinions or uncomfortable facts as 'rejected truths.' The humor lies in using a dramatic, dogmatic comic style to defend trivial or highly specific internet arguments, making the author look like a misunderstood martyr for their niche beliefs.