The MLP Infection meme, also known as the Ponyville Outbreak or MLP Pox, is a viral internet trend rooted in biological horror and creepypasta subcultures. It features beloved My Little Pony characters transformed into zombie-like creatures or victims of a mysterious, grotesque virus. Gaining significant traction on TikTok and digital art communities, the meme uses the sharp contrast between the show's colorful aesthetic and dark, apocalyptic themes to create an eerie visual narrative. Fans often use these templates to build elaborate 'Infection AUs' (Alternate Universes), documenting the collapse of Equestria through found-footage style captions and tragic character redesigns.