The Mia Khalifa meme encompasses various reaction images and videos featuring the media personality and former adult film star. Known for her distinctive glasses and expressive facial reactions, her image became a staple of internet culture, often used to signify shock, skepticism, or a 'knowing' glance. While she has transitioned into sports broadcasting and social media activism, her persona continues to thrive in meme circles, frequently appearing in situational humor where a specific, relatable reaction is required to deliver the punchline.