The 'Me and the Boys' meme features a group of four Spider-Man villains from the 1960s animated series—Electro, Vulture, Rhino, and Green Goblin—sporting exaggerated, mischievous grins. While variations existed earlier, the specific image of the four villains gained viral status in May 2019 after being posted on Reddit. The template is universally used to depict a group of friends participating in eccentric, often low-stakes, or nonsensical activities with a sense of shared camaraderie. Its popularity stems from the relatability of squad culture and the unsettling yet hilarious facial expressions of the characters, making it a staple for describing late-night adventures or inside jokes.