The Mass Effect meme culture primarily revolves around the iconic 'Dialogue Wheel' mechanic introduced by BioWare, which allows players to choose Commander Shepard’s responses. Famous variations include the 'I'm Commander Shepard and this is my favorite store on the Citadel' endorsement loop, the 'We'll bang, ok?' fan-edit catchphrase, and the 'Critical Mission Failure' screen. These memes often poke fun at the binary nature of moral choices in gaming, Shepard's awkward dancing, or the sometimes unintended consequences of selecting a seemingly innocent dialogue option that leads to a dramatic outburst in the game.