The 'Ludacris Ho' meme originates from the 2005 cinematic drama 'Hustle & Flow,' featuring the multi-platinum rapper Ludacris (Chris Bridges) as the erratic superstar character Skinny Black. In this specific scene, Skinny Black is being confronted by DJay (Terrence Howard) and his crew in a tense, humid bathroom encounter. The clip features the rhythmic and aggressive 'Ho!' ad-libs that were a staple of Ludacris’s early 2000s dirty south rap persona. This snippet has become a digital staple for its raw energy and the distinct 'stank face' Ludacris makes while delivering his lines. Commonly, the clip is used to represent skepticism, calling out a liar, or reacting with aggressive confusion to a ridiculous situation. It perfectly captures the emotion of being completely 'done' with someone's nonsense. Example captions include: 'When she says she doesn't have an attitude,' 'Me hearing the same lie for the 10th time today,' or 'When the beat drops and you lose all self-control.'