The 'Let's Go, Lesbians' meme originates from the high-octane comedy series Billy on the Street, hosted by Billy Eichner. In a recurring and iconic segment, Eichner sprints through the streets of New York City accompanied by a group of women, shouting the phrase to motivate them as they move frantically between locations. The clip became a viral sensation due to Billy's signature chaotic energy and the phrase's celebratory, inclusive, and hilariously urgent tone. Today, it is used across social media as a universal rallying cry for group activities, a reaction to exciting pop culture news, or simply to express a sense of manic urgency when getting friends ready for a night out.