The phrase 'Is This a JoJo Reference?' emerged as a meta-joke within the anime community, poking fun at the intense obsession fans of JoJo's Bizarre Adventure have with finding similarities between the real world and Hirohiko Araki’s long-running series. Because the manga is so expansive and covers diverse topics—ranging from tarot cards and classic rock bands to specific fashion poses and physics—nearly anything in pop culture can be jokingly interpreted as an homage to the show. The meme is typically used sarcastically to mock overzealous fans who 'reach' for connections, or genuinely to celebrate a subtle easter egg found in other media, making it one of the most versatile and enduring phrases in internet culture.